Ruthless siblings Roderick and Madeline Usher have built Fortunato Pharmaceuticals into an empire of wealth, privilege and power. But past secrets come to light when the heirs to the Usher dynasty start dying at the hands of a mysterious woman from their youth.

After a long journey, Philip arrives at the Usher mansion seeking his loved one, Madeline. Upon arriving, however, he discovers that Madeline and her brother Roderick Usher have been afflicted with a mysterious malady: Roderick’s senses have become painfully acute, while Madeline has become catatonic. That evening, Roderick tells his guest of an old Usher family curse: any time there has been more than one Usher child, all of the siblings have gone insane and died horrible deaths. As the days wear on, the effects of the curse reach their terrifying climax.